An automated system for rapid non-destructive enumeration of growing microbes.

(PLoS ONE), London, R., Schwedock, J., Sage, A., Valley, H., Meadows, J., Waddington, M., and Straus, D. (2010).

The power and simplicity of visual colony counting have made it the mainstay of microbiological analysis for more than 130 years. A disadvantage of the method is the long time required to generate visible colonies from cells in a sample.  This paper presents a new technology and platform that uses digital imaging of cellular autofluorescence to detect and enumerate growing microcolonies before they become visible to the eye, substantially reducing test times while maintaining key advantages of the current methods.


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